Moffitt Cancer Center, a world-renowned cancer treatment and research center, and Virogen Biotechnology Inc., a clinical-stage biotechnology company, announced a groundbreaking strategic partnership today. This collaboration aims to propel the development of Virogen's cutting-edge fusion protein, VG712 (Resimmune), addressing significant unmet needs in oncology and immunotherapy.
Published May 28 in Nature Communications, bioengineer Matthias Stephan, MD, PhD, and his Fred Hutch team report that a foaming liquid worked better than a standard liquid formulation at transferring gene therapy components to cells in laboratory studies.
Factor Bioscience Inc., a Cambridge, Massachusetts-based biotechnology company pioneering mRNA-based cell engineering, today announced that the United States Patent and Trademark Office (USPTO) has terminated three separate ex parte reexaminations of three U.S. patents owned by Factor.
Unlocking the biochemical secrets behind a perfect cup of black tea, scientists have identified the CsLOX6 gene as a master regulator in the formation of methyl jasmonate (MeJA), a key compound in tea's aroma. This breakthrough illuminates the intricate dance of genetics and chemistry that shapes the flavor profile of this globally adored drink.
A new study has assembled a complete telomere-to-telomere (T2T) genome for the Chinese bayberry, offering profound insights into the genetic basis of its fruit quality. This research marks a significant stride in understanding and enhancing the nutritional and economic value of this subtropical fruit species.
BACKGROUNDAlveolar bone defects caused by inflammation are an urgent issue in oral implant surgery that must be solved. Regulating the various phenotypes of macrophages to enhance the inflammatory environment can significantly affect the pr
BACKGROUNDThrombocytopenia 2, an autosomal dominant inherited disease characterized by moderate thrombocytopenia, predisposition to myeloid malignancies and normal platelet size and function, can be caused by 5’-untranslated region (UTR)
BACKGROUNDAtherosclerosis (AS), a chronic inflammatory disease of blood vessels, is a major contributor to cardiovascular disease. Dental pulp stem cells (DPSCs) are capable of exerting immunomodulatory and anti-inflammatory effects by secr
Diabetes mellitus (DM), an increasingly prevalent chronic metabolic disease, is characterised by prolonged hyperglycaemia, which leads to long-term health consequences. Although much effort has been put into understanding the pathogenesis o
BACKGROUNDA decreased autophagic capacity of bone marrow mesenchymal stromal cells (BMSCs) has been suggested to be an important cause of decreased osteogenic differentiation. A pharmacological increase in autophagy of BMSCs is a potential
In recent years, there has been considerable exploration into methods aimed at enhancing the regenerative capacity of transplanted and/or tissue-resident cells. Biomaterials, in particular, have garnered significant interest for their poten
BACKGROUNDBone healing is a complex process involving early inflammatory immune regulation, angiogenesis, osteogenic differentiation, and biomineralization. Fracture repair poses challenges for orthopedic surgeons, necessitating the search
Unlike central nervous system injuries, peripheral nerve injuries (PNIs) are often characterized by more or less successful axonal regeneration. However, structural and functional recovery is a senile process involving multifaceted cellular
BACKGROUNDAplastic anemia (AA) presents a significant clinical challenge as a life-threatening condition due to failure to produce essential blood cells, with the current therapeutic options being notably limited. AIMTo assess the therapeu
BACKGROUNDAcute kidney injury (AKI) is a common clinical syndrome with high morbidity and mortality rates. The use of pluripotent stem cells holds great promise for the treatment of AKI. Urine-derived stem cells (USCs) are a novel and versa
BACKGROUNDHuman induced pluripotent stem cell (hiPSC) technology is a valuable tool for generating patient-specific stem cells, facilitating disease modeling, and investigating disease mechanisms. However, iPSCs carrying specific mutations
BACKGROUNDEmbryonic stem cells (ESCs) serve as a crucial ex vivo model, representing epiblast cells derived from the inner cell mass of blastocyst-stage embryos. ESCs exhibit a unique combination of self-renewal potency, unlimited prolifera
Volume 29, Issue 2 of SLAS Technology, includes three original research articles covering skin cutaneous melanoma, glycan-bead coupling and acoustic ejection mass spectrometry, and eight articles from the Advances in Synthetic Biology Special Issue.
Cold stress significantly hampers tomato growth and yield. Recent research reveals that 5-aminolevulinic acid (ALA) enhances cold tolerance in tomatoes by regulating the SlMYB4/SlMYB88-SlGSTU43 gene module. This discovery opens new avenues for genetic engineering to develop cold-resistant tomato varieties, potentially ensuring better crop resilience and productivity under low-temperature conditions.
A new assembly toolkit, an efficient assembly toolkit (PMAT), is set to revolutionize the study of plant mitochondrial genomes (mitogenomes), offering an unprecedented approach to understanding plant evolution and cytoplasmic male sterile line breeding. This tool stands to overcome significant challenges in the complete assembly of plant mitogenomes, a task previously hindered by complex recombination events and horizontal gene transfers.
The U.S. Food and Drug Administration recently approved two new wound management products that include patented hydrogels invented by University of Delaware researchers. The unique UD hydrogel materials self-assemble to form a 3D matrix compatible with living cells.
Current methods to model or correct mutations in live cells are inefficient, especially when multiplexing — installing multiple point mutations simultaneously across the genome. Researchers from the UC San Diego have developed new, efficient genome editing tools called multiplexed orthogonal base editors (MOBEs) to install multiple point mutations at once.
This study investigates the genetic regulation of volatile production in melons, identifying over 1000 quantitative trait loci (QTLs) affecting aroma and ripening. Key findings highlight specific chromosomes that influence ester and aldehyde levels, contributing to unique aromas in climacteric and non-climacteric melons, aiding breeding programs aimed at enhancing fruit quality.
A research team has developed a novel conceptual framework for designing plastic-greenhouse soil profiles that cater to the needs of smallholder farmers.
A research team has reviewed the role of MicroRNA156 (miR156) in horticultural plants, uncovering its significant influence on a variety of biological processes such as vegetative growth, floral induction, and stress response.
A research team has meticulously analyzed the transcriptional response of Impatiens walleriana to Plasmopara obducens infection, revealing between 3,000 and 4,500 differentially expressed transcripts at various stages of the disease.
A study has tapped into the peach genome, creating large-scale gene coexpression networks (GCNs) that predict gene functions and streamline the peach breeding process. This innovative approach addresses the complex task of identifying genes linked to desirable breeding traits in peaches.
A study introduces an automated machine learning (Auto-ML) model that predicts the freezing tolerance of grapevines in real-time, a critical advancement for sustainable grape production in cooler climates. This model leverages hourly temperature data and varietal specifics to forecast cold hardiness, a significant step towards precision viticulture.
Recent research has unveiled the genetic foundations of resistance in strawberries to Macrophomina, a formidable soilborne disease. Employing cutting-edge breeding strategies and genomic analysis, scientists have pinpointed crucial genetic loci responsible for resistance, heralding a new era of more robust strawberry varieties.
A recent study has unlocked the genetic secrets behind the sweetness of strawberries, a key factor in consumer preference. The research identifies key genetic markers that influence both the sugar content and yield of strawberries, offering a significant step forward in the breeding of sweeter, more productive varieties.
New genomic insights from researchers unveil critical genes influencing apple fruit size and shape. Through a comprehensive genome-wide association study, the study identifies several genetic markers linked to these traits, offering potential for enhanced breeding strategies.
A new study has uncovered a genetic treasure trove within the melon genome that could revolutionize the plant's defense against pests and diseases. Researchers have identified a cluster of genes that bestow resistance to both powdery mildew and aphids, two of the most devastating threats to melon crops worldwide.
Biotechnological innovation meets horticulture as researchers unveil a cutting-edge genome editing protocol for grapes. This novel technique, integrating protoplast culture with CRISPR-Cas9, facilitates the regeneration of non-chimeric, transgene-free plants across a spectrum of grape varieties.
A study by researchers at Washington University School of Medicine in St. Louis has found that repeat vaccination with updated versions of the COVID-19 vaccine promotes the development of antibodies that neutralize a wide range of variants of the virus that causes COVID-19, as well as related coronaviruses.
Researchers have developed a groundbreaking point-of-care detection method for Vibrio parahaemolyticus, a bacterium responsible for a significant number of foodborne illnesses. The new platform, leveraging recombinant polymerase amplification (RPA) and the CRISPR/Cas12a system combined with an immunochromatographic test strip (ICS), offers a low-cost, simple, and visually intuitive solution for the rapid detection of this pathogen in seafood.
From lemur poop to good old human poop, our waste has a story to tell. The U.S. Department of Energy’s (DOE) Argonne National Laboratory’s Environmental Sample Preparation and Sequencing Facility (ESPSF) has the tools and technology to get to the bottom of genetic mysteries from the natural world. Facility Manager Sarah Owens can help shed light on the quirkier side of genetics.
Disc-related back pain may one day meet its therapeutic match: gene therapy delivered by naturally derived nanocarriers that, a new study shows, repairs damaged discs in the spine and lowers pain symptoms in mice.
F. William Studier, a senior biophysicist emeritus at the U.S. Department of Energy's 'Brookhaven National Laboratory, has won the 2024 Richard N. Merkin Prize in Biomedical Technology for his development in the 1980s of an efficient, scalable method of producing RNA and proteins in the laboratory.
Hae Choon Chang, President of the World Institute of Kimchi (WiKim) announced on April 22 that the institute has developed a 'bio-refactoring-based upcycling technology' that can convert cabbage byproducts discarded as waste during the food manufacturing process into biodegradable plastics.
A new study led by the University of Portsmouth in England has developed an innovative method to customise and strengthen DNA origami structures, which could lead to advances in medicine, biotechnology, and beyond.
The Korea Institute of Science and Technology (KIST) announced that Dr. Sang Soo, Han and Dr. Donghun, Kim of the Computational Science Research Center and Professor Kwan-Young Lee of the Department of Chemical Engineering and Biotechnology at Korea University (President Kim Dong-won) have developed a bespoke synthesis platform of nanomaterials using AI and robotics, called Smart Lab.
In the field of biomedical research and genomics, the advancement of bioinformatics technologies and tools is opening new frontiers in the understanding of diseases and their diagnosis and treatment.
Researchers report in ACS Central Science that they have 3D printed a bioink containing plant cells that were then genetically modified, producing programmable materials. Applications could someday include biomanufacturing and sustainable construction.
Not for public release
This news release is embargoed until 30-Apr-2024 7:00 AM EDT
Released to reporters: 26-Apr-2024 8:10 AM EDT
A reporter's PressPass is required to
access this story until the embargo expires on 30-Apr-2024 7:00 AM EDT
The Newswise PressPass gives verified journalists access to embargoed stories.
Please log in to complete a presspass application.
If you have not yet registered, please Register. When you
fill out the registration form, please identify yourself as a reporter in order to
advance to the presspass application form.
Not for public release
This news release is embargoed until 30-Apr-2024 7:00 AM EDT
Released to reporters: 26-Apr-2024 3:15 PM EDT
A reporter's PressPass is required to
access this story until the embargo expires on 30-Apr-2024 7:00 AM EDT
The Newswise PressPass gives verified journalists access to embargoed stories.
Please log in to complete a presspass application.
If you have not yet registered, please Register. When you
fill out the registration form, please identify yourself as a reporter in order to
advance to the presspass application form.
Miriam Merad, MD, PhD, a world-renowned immunologist, has been appointed Dean for Translational Research and Therapeutic Innovation of the Icahn School of Medicine at Mount Sinai. The appointment reaffirms Icahn Mount Sinai’s commitment to pioneering medical progress and catalyzing the rapid advancement of research innovation. Dr. Merad, the Mount Sinai Professor in Cancer Immunology, will also continue to serve as the founding Chair of the Department of Immunology and Immunotherapy, Director of the Marc and Jennifer Lipschultz Precision Immunology Institute, and Director of the Human Immune Monitoring Center.
As Dean, Dr. Merad aims to elevate early clinical trials at Icahn Mount Sinai, streamline the clinical trial process, cultivate a culture of mechanistic clinical trials throughout the campus, and forge stronger partnerships with the pharmaceutical and biotech sectors.
The repair of bone tissue damage is a complex process that is well-orchestrated in time and space, a focus and difficulty in orthopedic treatment. In recent years, the success of mesenchymal stem cells (MSCs)-mediated bone repair in clinica
Wound repair is a complex challenge for both clinical practitioners and researchers. Conventional approaches for wound repair have several limitations. Stem cell-based therapy has emerged as a novel strategy to address this issue, exhibitin
Coronavirus disease 2019 (COVID-19) is an acute respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infection typically presents with fever and respiratory symptoms, which can progress to
BACKGROUNDMesenchymal stem cells (MSCs) have been extensively studied for therapeutic potential, due to their regenerative and immunomodulatory properties. Serial passage and stress factors may affect the biological characteristics of MSCs,
RSS