A new study suggests making a transition from “old school” genetics to “new school” genomics for species conservation purposes probably isn’t necessary in all cases.
Bats have acquired remarkable traits throughout their evolution. They’re the only mammals that can fly, and they live much longer than other animals their size. But perhaps most impressive is their robust immune system. It protects bats from viruses that wreak havoc in humans, like COVID-19 or Ebola. It also keeps bats relatively cancer-free. How? According to Cold Spring Harbor Laboratory (CSHL) scientists, it’s all in the genes.
A team of European researchers has developed a new test that can accurately measure biological aging in a clinical setting. The discovery was made while studying patients for the aging effects of chronic kidney disease.
An international collaboration is aiming to improve global health by uncovering the effects of genomic and environmental diversity on differences in disease risk observed across the global population, thanks to a new partnership of 20 research groups from around the world.
A new study has unravelled a crucial link between how cancer cells cope with replication stress and the role of Taurine Upregulated Gene 1 (TUG1). By targeting TUG1 with a drug, the researchers were able to control brain tumor growth in mice, suggesting a potential strategy to combat aggressive brain tumors such as glioblastomas.
Basic Research Findings by Johns Hopkins Scientists Focus on Gene Sequencing, Hearing Loss and a Brain Disorder
Evolutionary biologists have for the first time decoded the genetic lineage of a famous killer whale and a pod that once worked alongside whale hunters off the coast of New South Wales.
Multiomics3 analysis that integrates different layers of profiles altogether is challenging, since the number of variables in profile substantially differ from each other. For instance, gene expression profile and genomic DNA methylation profile are often analyzed together, however, there are only tens of thousands of genes, whereas the number of DNA methylation sites are as many as tens of millions.
An international team of scientists has identified nearly a dozen genes that contribute to calcium buildup in our coronary arteries that can lead to life-threatening coronary artery disease, a condition responsible for up to one in four deaths in the United States. Doctors may be able to target these genes with existing medications – or possibly even nutritional supplements – to slow or halt the disease’s progression.
Through a novel approach detailed in Nature, a massive computational analysis of microbiome datasets more than doubled the number of known protein families. This is the first time protein structures have been used to help characterize the vast array of microbial “dark matter.”
Generating specific cell lineages from induced pluripotent stem cells and embryonic stem cells is the holy grail of regenerative medicine.
Early predictors of cancer evolution under therapy have been identified using an artificial intelligence program to analyze data from tumor samples of patients with glioma, an aggressive and often fatal type of brain cancer. This use of machine learning in precision medicine shows signs of significantly better performance than current grading and diagnostic models.
The Faculty of Medicine, Chulalongkorn University, cordially invites all to attend the “Thailand Hub of Talent for Cancer Immunotherapy International Conference: Portal to Global Collaboration for Next Generation Cell and Gene Therapy Development” on November 16-17, 2023 at Bhumisiri Mangklanusorn Building, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
The “Margaritaville” in Jimmy Buffett’s famous song isn’t a real place, but it’s long been associated with the Florida Keys. This string of tropical islands is home to the only living coral barrier reef in the continental US, along with many animals found nowhere else in the world.
Johns Hopkins Medicine experts lead the longest-running clinic for people with dwarfism and other skeletal conditions. Started in the late 1950s, the clinic, now called the Kathryn and Alan C.
The software's creators have used it to study cancer’s microbiome and made it freely available to the research community.
Research sheds light on how genetics influences the growth of the placenta and reveals a link to increased risk of disease in the mother.
A team of New York University computer scientists has created a neural network that can explain how it reaches its predictions. The work reveals what accounts for the functionality of neural networks—the engines that drive artificial intelligence and machine learning—thereby illuminating a process that has largely been concealed from users.
Scientists testing a new method of sequencing single cells have unexpectedly changed our understanding of the rules of genetics.
In 2019, St. Jude lentiviral gene therapy restored the immune system in multiple infants of X-linked severe combined immunodeficiency disorder (SCID-X1) or “bubble boy disease” at the DNA level. These children can now produce functional immune systems.
African Americans have long been known to be at increased risk of kidney disease due to a dangerous genetic mutation that creates a hole in the kidney cells, but Vanderbilt University Medical Center (VUMC) researchers have now discovered a protective genetic mutation that covers the hole to eliminate the risk.
Scientists testing a new method of sequencing single cells have unexpectedly changed our understanding of the rules of genetics.
Circulating tumor DNA (ctDNA) is emerging as a blood-based biomarker for many solid tumor types, including melanoma.
A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 18, entitled, “Biomedical generative pre-trained based transformer language model for age-related disease target discovery.”
A new paper in Molecular Biology and Evolution, published by Oxford University Press, for the first time provides a comprehensive set of genomic resources for pangolins, sometimes known as scaly anteaters, that researchers believe will be integral for protecting these threatened mammals.
The American College of Surgeons (ACS) strongly supports the Find it Early Act (H.R. 3086).
This most recent work from the Umen lab gets at the critical control mechanism for sex determination in single-celled and multicellular algae. The capacity to produce distinct mating types (e.g. male and female) is the foundation for reshuffling of genetic material within a species, which maintains genetic diversity and capacity to adapt in different environments.
UMass Amherst researchers have pushed forward the boundaries of biomedical engineering one hundredfold with a new method for DNA detection with unprecedented sensitivity.
Commercial whaling in the 20th century decimated populations of large whales but also appears to have had a lasting impact on the genetic diversity of today’s surviving whales, new research from Oregon State University shows.
During a recent review of the U.S. Fish and Wildlife Service’s recovery plans for more than 200 endangered and threatened vertebrate species in the United States, Michigan State University researchers made an interesting discovery.
Using laboratory-grown cells from humans and genetically engineered mice, scientists at Johns Hopkins Medicine say they have evidence that modifying a specific protein in immune white blood cells known as CD8+ T cells can make the cells more robust, potentially opening the door for better use of people’s own immune system T cells to fight cancer.
Scientists at St. Jude Children’s Research Hospital unraveled the genetics increasing the chance of survivors developing a second cancer later in life and its severity and prognosis to guide future cancer prevention.
Investigators from Rutgers Cancer Institute of New Jersey and RWJBarnabas Health, the state’s leading cancer program and only National Cancer Institute-designated Comprehensive Cancer Center, investigated genomic alterations based on KRAS status to identify mutations in patients with KRAS wild type (WT).
As one of just six sites in the country chosen for a new consortium of the National Institutes of Health (NIH), UTHealth Houston School of Public Health in Brownsville will use multi-omics in combination with environmental, epidemiologic, and clinical data, along with social determinants of health, to study non-alcoholic and non-viral liver disease in Hispanics/Latinos.
To commemorate this 20-year milestone and to mark National Breast Cancer Awareness Month, NIEHS developed a suite of products including a 10-minute video available in English and available with Spanish captions, to showcase how the Sister Study started, what it has accomplished, and to spotlight the participants who make it all possible.
Vanderbilt University Medical Center’s (VUMC) award-winning original podcast series, “Vanderbilt Health DNA: Discoveries in Action” (DNA), returns to podcast feeds for Season 4 with conversations about how the future of tech, economic and cultural elements are shaping medicine, work and well-being.
An international team of researchers has released a landmark study on contemporary evolutionary change in natural populations. Their study uses one of the largest genomic datasets ever produced for animals in their natural environment, comprising nearly 4,000 Darwin’s finches.
Scientists show the extraordinary diversity of cichlid fish in Africa’s Lake Victoria was made possible by ‘genetic recycling’ - repeated cycles of new species appearing and rapidly adapting to different roles in the ecosystem.
The reasons why people attempt suicide are complex and include external triggers like trauma and stress, as well as inherited genetic factors. A new study has identified 12 DNA variants, or variations in the human genetic code, that are associated with risk of attempting suicide.
Regel Therapeutics, a next generation gene therapy company utilizing proprietary technology to modulate gene expression, today announced that based upon the groundbreaking work of its Co-Founder and Chief Scientific Officer Dr. Navneet Matharu.
Some substances in medicines, household items and the environment are known to affect prenatal child development.
Elk treponeme-associated hoof disease, previously thought to be limited to deformations in elks’ hooves, appears to create molecular changes throughout the animal’s system, according to epigenetic research from Washington State University.
Irvine, Calif., Sept. 28, 2023 — With a two-year, $2 million grant from the California Institute for Regenerative Medicine, the University of California, Irvine has earned membership in CIRM’s Cell and Gene Therapy Manufacturing Network.
Researchers at Washington University in St. Louis have developed a technique called sonobiopsy that uses ultrasound and microbubbles to disrupt the blood-brain barrier temporarily and allow RNA, DNA and proteins from the brain to spill out into the blood, where they can be detected and analyzed.
A discovery of a mutation in the gene ACTA2 has given researchers, led by Dianna Milewicz, MD, PhD, with UTHealth Houston, insight into understanding the cause of a rare and progressive problem with arteries in the brain and a cause of strokes in young children, called moyamoya disease.
Researchers at the Beckman Institute for Advanced Science and Technology have established the protein p53 as critical for regulating sociability, repetitive behavior, and hippocampus-related learning and memory in mice, illuminating the relationship between the protein-coding gene TP53 and neurodevelopmental and psychiatric disorders.
Stanford Medicine investigators and their colleagues sifted through a jumble of genes implicated in neurodevelopmental disorders and identified dozens of disparate troublemakers with similar effects.
Two nationally recognized experts in cloning and stem cell science from the University of Houston, Wa Xian and Frank McKeon, are reporting that five lung stem cell variants dominate the lungs of patients with advanced cystic fibrosis (CF), and that these variants drive key aspects of CF pathology including inflammation, fibrosis and mucin secretion.
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