Medical Meetings Research News and Press Releases

To compare the outcomes of patients receiving lungs transplanted after undergoing ex vivo lung perfusion (EVLP) versus those transplanted conventionally at the Toronto General Hospital, Aadil Ali, PhD, and coauthors looked at 14 years of data from the Toronto Lung Transplant Database.

Research Results MEDICINE

1-May-2023 4:10 PM EDT

Long-term Outcome of Patients with Peripheral Ground Glass Opacity Dominant Lung Cancer After Sublobar Resections

American Association for Thoracic Surgery (AATS)

In 2011, Makoto Suzuki, MD, and a team of associates from across Japan embarked on a long-term study of the safety and efficacy of sublobar resections for ground-glass opacity–dominant (GGO) peripheral lung cancer.

Research Results MEDICINE

1-May-2023 3:35 PM EDT

Results of Early Monitoring of Circulating Tumor DNA in Resected Early-Stage Non-Small Cell Lung Cancer

American Association for Thoracic Surgery (AATS)

Among the questions that cancer patients ask following their surgeries are, “Will it come back? Do I need additional treatment?”

Research Results MEDICINE

1-May-2023 4:25 PM EDT

Prognostic Utility of a Novel Risk Prediction Model for 1-Year Mortality Following Surgery for Congenital or Acquired Heart Disease

American Association for Thoracic Surgery (AATS)

Congenital heart disease (CHD) is the most common type of birth defect and the leading cause of mortality from birth defects, affecting about 1% of all live births per year in the United States. With advances in medical therapies and surgical techniques, the survival outcomes of patients with CHD have improved dramatically over the years.

Research Results MEDICINE

1-May-2023 3:55 PM EDT

Apixaban vs. Warfarin in Patients with an On-X Mechanical Aortic Valve

American Association for Thoracic Surgery (AATS)

Although the On-X aortic valve and apixaban have been approved for use by the U.S. Food and Drug Administration (FDA), they had not been approved to be used together. Between May 2020 and September 2022, the PROACT Xa randomized, multicenter, open-label trial compared the direct factor Xa inhibitor apixaban (Eliquis) with warfarin in patients with bileaflet carbon aortic valves.

Research Results MEDICINE

1-May-2023 4:30 PM EDT

Safety and Efficacy of Delaying Nighttime Lung Transplantation

American Association for Thoracic Surgery (AATS)

Lung transplantation is routinely performed at night because of the unpredictability of donor organ procurement. Late start-times for complex operations such as lung transplantation have been associated with adverse outcomes.

Research Results MEDICINE

1-May-2023 4:05 PM EDT

Non-elective CABG Outcomes are Adversely Impacted by COVID Infection, but not by Altered Processes of Care

American Association for Thoracic Surgery (AATS)

As thoracic researchers consider the myriad effects of COVID-19, they are looking at the impacts of the disease on patients and treatments, as well as care and treatment during the pandemic.

Research Results MEDICINE

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Curated News: Medical Meetings

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The landscape of glioma-infiltrated immune cells after immune checkpoint blockade treatment

Notch2 deficiency generates functionally impaired cDCs and macrophages that correlates with intestinal dysbiosis and low-grade inflammation

A combination of TLR9 and STING agonists induces potent neopeptide-specific T cell immunity and improves ICB efficacy in tumor models

Microanatomical lipid niche controls intestinal memory B cell migration and effector function

Pyruvate dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic reprogramming

Single cell RNA sequencing reveals heterogenous immune landscape of tumor infiltrated immune cell population against glioblastoma

Macrophages and neutrophils in lymph node granulomas from Mycobacterium tuberculosis-infected macaques have immunoregulatory phenotypes

Robust T cell responses to the Pfizer/BioNTech vaccine compared to infection and evidence of attenuated CD8+ T cell responses due to COVID-19

Pro-resolution lipid mediator maresin-1 reduces inflammation, promotes neuroprotection, and prevents disease progression in multiple sclerosis model of autoimmunity

Oxidized phospholipid oxPAPC induces a dysfunctional Th1-like phenotype in regulatory T cells

Cytometric analysis authenticates adjuvanticity of interferon-γ and suggests potential synergy with toll-like receptor agonists

Longitudinal analysis reveals age-dependent immune responses to SARS-CoV-2 infection in a mouse model

Effect of estrogen signaling in CD8 T cell mediated antiviral response

Engineering antibody fusion proteins for targeted intracellular therapeutic delivery

Design and characterization of a tumor-retained interleukin-2 cytokine/antibody fusion protein for cancer immunotherapy

A commensal-derived exopolysaccharide regulates ILC3-mediated diseases

Cross-reactive seasonal coronavirus antibody responses contribute to antibody- mediated effector functions against SARS-CoV-2 in individuals in Kenya

Tunable dynamics of B cell selection in gut germinal centers

IL-1 signaling directs the prioritization of inflammatory sites in a model of postoperative pulmonary infection

Systems approaches to characterize the local heterogeneities in NK cell antitumor immunity in MHC I-disparate human non-small cell lung cancer

Premature Treg induction in early life results in FoxP3 instability post-weaning

SARS-CoV-2 seroreversion is associated with a decrease in T cell functionality in children

Design and optimization of a novel proteomimetic polymer nanoplatform for the co-delivery of antigens with adjuvants

Tunable dynamics of B cell selection in gut germinal centers

Reshaping the anti-tumor CD4 T-cell repertoire contributes to oncolytic virus therapeutic efficacy in malignant glioma

The glucose transporter GLUT4 tethers RIG-I-like receptors to suppress antiviral immunity

Regulation of myeloid cells and inflammation marks increased susceptibility in a genetic model of acute viral infection-induced tissue damage

Bio-active lipids protect against immune-related adverse events due to immune checkpoint blockade therapy

Murine CD4+ T cells exhibit sexually dimorphic responses to estrogen signaling

Prenatally educated friendly NK cells regulate allo-specific T cell responses through expansion of Foxp3+CD4+Treg cells and suppression of Type 1 and 17 CD8+T cell responses

Dynamics of immune cells in the fetal brain upon viral inflammation

Overlapping Mendelian disorders of immunity and metabolism shape CD4+ T cell immunometabolism

Synergy between anti-commensal antibodies and IL-10 in gut homeostasis and disease

Inhibition of distinct glycolytic enzymes produces differential effects on CD4 T cell function

Diabetic wound keratinocytes induce macrophage JMJD3-mediated Nlrp3 expression via IL1R signaling

lntercellular mitochondria transfer rescues aerobic respiration in metabolically compromised macrophages in vitro and in vivo

Mitochondrial metabolic flexibility is critical for CD8 T cell anti-tumor immunity

Microanatomical lipid niche controls intestinal memory B cell migration and effector function

Reshaping the anti-tumor CD4 T-cell repertoire contributes to oncolytic virus therapeutic efficacy

IL-10 promotes tissue-resident memory T cells (TRM) in the respiratory tract during SARS-CoV-2 infection in rhesus macaques

Interferon-lambda accelerates viral clearance and regulates CD8+ T cells immunity in a murine model of SARS-CoV-2 infection

Pre-existing immunity modulates responses to mRNA boosters

Synthetically mannosylated antigens impair the antigen-specific humoral immune response and prolong the therapeutic efficacy of immunogenic protein drugs

Clinical Outcomes of more than 500 Lung Transplants using Ex vivo Lung Perfusion: A Large-Volume, Single-Center Retrospective Analysis

Long-term Outcome of Patients with Peripheral Ground Glass Opacity Dominant Lung Cancer After Sublobar Resections

Results of Early Monitoring of Circulating Tumor DNA in Resected Early-Stage Non-Small Cell Lung Cancer

Prognostic Utility of a Novel Risk Prediction Model for 1-Year Mortality Following Surgery for Congenital or Acquired Heart Disease

Apixaban vs. Warfarin in Patients with an On-X Mechanical Aortic Valve

Safety and Efficacy of Delaying Nighttime Lung Transplantation

Non-elective CABG Outcomes are Adversely Impacted by COVID Infection, but not by Altered Processes of Care

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